Estrogen hormone physiology: Reproductive findings from estrogen receptor mutant mice
نویسندگان
چکیده
منابع مشابه
An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.
Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate these mutated ERs or altered transcriptional activation function, expression vectors containing wild-...
متن کاملHormone-independent Activity from a Metastatic Breast Cancer An Estrogen Receptor Mutant with Strong
activity is also thought to be modulated by phosphorylation and dephosphorylation on multiple serine and tyrosine residues through more or less defined signaling pathways (5, 6). It is well accepted that the presence of ER identifies those breast cancer patients with a lower risk of disease recurrence and better survival, who may also have a better response to endocrine interven tions (7). The ...
متن کاملRole of estrogen receptor in uterine stroma and epithelium: Insights from estrogen receptor / mice
In this study, we compared the uterine tissue of estrogen receptor (ER) / mice and their WT littermates for differences in morphology, proliferation [the percentage of labeled cells 2 h after BrdUrd injection and EGF receptor (EGFR) expression], and differentiation (expression of progesterone receptor, E-cadherin, and cytokeratins). In ovariectomized mice, progesterone receptor expression in th...
متن کاملEstrogen and Growth Hormone and their Roles in Reproductive Function
The aim of this study was to review the effect of estrogen on growth hormone secretion and the roles of estrogen and growth hormone in reproductive function. Estrogen is the main hormone affecting growth, development, maturation and functioning of reproductive tract as well as the sexual differentiation and the behavior. Growth hormone is also important factor in sexual maturation and attainmen...
متن کاملEstrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice.
It has been shown that the female sex hormones have a protective role in the development of angiotensin II (ANG II)-induced hypertension. The present study tested the hypotheses that 1) the estrogen receptor-alpha (ERalpha) is involved in the protective effects of estrogen against ANG II-induced hypertension and 2) central ERs are involved. Blood pressure (BP) was measured in female mice with t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reproductive Biology
سال: 2014
ISSN: 1642-431X
DOI: 10.1016/j.repbio.2013.12.002